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Mounjaro mimics the effects of a hormone called glucagon-like peptide-1 (GLP-1) in the body. GLP-1 is naturally produced in the intestines and helps regulate blood sugar levels. By activating GLP-1 receptors, Mounjaro helps stimulate the release of insulin from the pancreas, reduce liver glucose production, and slow gastric emptying. These measures help lower blood sugar levels in people with type 2 diabetes.
The drug is typically used in combination with diet and exercise to improve blood sugar control in adults with type 2 diabetes. It is available as a once-weekly injection and is administered subcutaneously (under the skin).
In clinical studies, Mounjaro has been shown to effectively lower blood sugar levels, reduce body weight, and improve cardiovascular outcomes. It has also been associated with a lower risk of hypoglycemia (low blood sugar) compared to some other diabetes medications.
Results from the SUSTAIN-6 trial showed that Mounjaro significantly reduced the risk of major adverse cardiovascular events (MACE), including cardiovascular death, non-fatal myocardial infarction and non-fatal stroke. The study found that Mounjaro reduced the risk of MACE by 26% compared to placebo over a median follow-up of 2.1 years.
In addition to reducing MACE risk, Mounjaro also demonstrated benefits in other cardiovascular outcomes. It significantly reduced the risk of cardiovascular death by 39% compared to placebo. In addition, Mounjaro was associated with a 51% lower risk of all-cause mortality (death from any cause) compared to placebo.
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